Research Models

The rapid worldwide growth in the incidents of cardiovascular, metabolic and renal disease has lead to an accelerated effort to find cures for these diseases. PhysioGenix supports these research efforts with our best in class research models. 

Non-Obese, type 2 Diabetes and Renal Disease Models

  • T2DN rat (genetic model) 
  • Goto-Kakizaki (GK) rat 

Obese, Type 2 Diabetes

  • Zucker Diabetic Fatty (ZDF) rat (genetic model) 
  • fa/fa rat (genetic model) 
  • db/db mouse (genetic model) 
  • ob/ob mouse (genetic model) 
  • DIO mouse (diet induced) 

Obese Metabolic Syndrome Model 

  • Obese Zucker rat 

Non-Obese, Type 1 Diabetes

  • STZ rat model 
  • NOD mouse 

Hypertensive and Renal Failure Models 

  • Dahl/Salt Sensitive (Dahl/SS) rat 
  • Dahl/SS SS-13BN rat for normotensive control model 

Hypertensive Model 

  • Spontaneously Hypertensive (SHR) rat

 

Our highly skilled team is capable of delivering a wide-range of diabetes studies utilizing surgical, technique and chemical models. 
  • STZ - Chemically induced pancreatic necrosis of the insulin producing beta cells to produce an animal model that has type I diabetes. 
  • 5/6 Nephrectomy - Surgical removal of one kidney and 2/3 of the other kidney leading to distinct rises in blood urea nitrogen and in renal excretion of proteins indicate the impairment of the kidney. 
  • Clamp - The hyperglycemic clamp is a way to quantify beta-cell response to glucose. The hyperinsulinemic euglycemic clamp is a way to quantify sensitivity to insulin. 
  • High Fructose Diet 
  • High Sucrose/Low Copper Diet 
Download PhysioGenix's Disease Models for rat 
Download PhysioGenix's Disease Models for mice