T2DN: A Type-2 Diabetes Model

A Genetically Modified GK Diabetic Rat that Develops Nephropathy

T2DN Rats: Basement Membrane Thickening

Comparison of Treatments in T2DN Rats

Proteinuria in T2DN rats. Significant differences were detected after 2 weeks of treatment and continued for the duration of the study in rats treated with ACE inhibitor, Metalloproteinase Inhibitor (MPI) (Low dose), combination of ACE inhibitor and MPI (Low dose), and MPI (High dose). Blood Pressure in T2DN rats. Significant differences were detected after 1 month of treatment and continued for the duration of the study in rats treated with ACE inhibitor, and combination of ACE inhibitor and MPI (Low dose).

Effect of Lisinopril and MPI on Renal and MPI on Renal Histology

Treatment of the T2DN with an ACE inhibitor decreases expansion of mesangial matrix, thickening of the basement membrane, glomerulosclerosis and reduces overall renal damaged

These glomeruli exhibit thickening of the basement membrane of the Bowman’s space and mesangial matrix expansion leading to focal segmental glomerulosclerosis and renal interstitial fibrosis. Treatment with ACE inhibitor significantly reduced the mesangial expansion and renal interstitial fibrosis. Treatment with MPI had similar histological benefits.

Comparison of Diabetic Models