In Vivo Capabilities

In Vivo Pharmacology

Available in mice or rats via multiple routes of administration.
  • Efficacy
  • Pharmacodynamic (PD) / Pharmacokinetic (PK)
  • Basic Safety Assessments
    • Tolerability studies
    • Dose range finding studies
    • Observations: clinical signs, mortality, body weight,
      and food and water intake 
    • Clinical chemistry and urine analysis
  • Post Mortem
    • Clinical blood chemistry 
    • Metabolic assays 
    • Organ weights 
    • Gross necropsy

Diagnostic Assays

  • Glucose Tolerance
  • Test Insulin Tolerance
  • Test Proteinuria Assay
  • Albuminuria Assay

Blood Pressure Measurements

  • Telemetry for continuous measurement of blood pressure in free moving animals during a chronic drug testing protocol. 
  • Femoral catheter implant for direct measurement of blood pressure changes during acute drug testing. 
  • Tail cuff for non-invasive measurement of blood pressure during acute drug testing.

Blood Chemistry

We can provide glucose, hematology, electroyte, liver enzymes, nitrogen elements, proteins, lipids, and ratios to our clients. 
  • General chemistry: albumin (ALB), alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN), CA, cholesterol (CHOL), creatinine (CREAT), CRE, glucose (GLU), total bilirubin (TBIL), total protein (TP), creatinine kinase (CK), lactase dehydrogenase (LDH), postasium (K), chloride (CL), bicarbonate (BICARB)
  • Lipid panel: cholesterol (CHOL), cholesterol/high-density lipoprotein ratio (CHOL/HDL), high-density lipoprotein (HDL), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL)
  • Hormones: insulin, glucagon, leptin, somatostatin, IGF-1
  • Growth Factors: VEGF
  • Glycosylated hemoglobin (HbA1c)
  • Uric acid
  • Calculations based off of clinical chemistry: creatine clearance, anion gap
  • Other other plasma and blood chemistry upon request

Also, view our measurable biomarkers page.

Histology

Histology services include routine preparation of paraffin-embeddedand frozen sections for numerous immunoflurescence and immunohistochemical stains. Common stains in many of our studies include hematoxylin and eosin (H&E) and Masson's trichrome. Expert evaluation with complete report and electronic record of sections.

Surgery and Drug Delivery

Our surgical team's experience and knowledge are capable of providing standard or customized surgical procedures in a variety of research models.  Common procedures include uninephrectomy, implantation of femoral catheter, jugular catheter, telemetry devices and osmotic pumps.  Delivery systems and areas include:
  • Arterial/venous
  • Portal vein
  • Intramyocardial
  • Intrahepatic
  • Intrathecal
  • Organ specific
  • Gross necropsy
Acute and chronic dosing protocols by
  • Oral gavage
  • Subcutaneous
  • Intraperitoneal injection
  • Intramuscular
  • Tail vein injection
  • Osmotic pump implantation

Statistics

General services accompanying most studies - 
  • Statistical analysis
  • Data interpretation by subject matter experts 
  • Follow-up consulting